Obesity and Diabetes: Pathophysiology of Obesity-Induced Hyperglycemia and Insulin Resistance

Abstract

Insulin resistanceInsulin resistance along with type 2 diabetesDiabetes (T2D) is some of the complications of obesityObesity. Insulin resistanceInsulin resistance occurs due to the increased discharge of fatty acids, lipids, and other advancing factors, by the adipose tissueAdipose tissue, leading to a myriad of complications. Several other substances namely glycerol, enzymes, inflammatory factors, and hormones are also involved in the overall mechanism. At the point when resistance towards insulin occurs, along with abnormally functioning $β$-cells$\Beta$-cells, the overall burden of the inability to control elevated glucose levels in the blood ensues. Anomalies in $β$-cell$\Beta$-cells are thus more critical in the development of T2D and its related symptoms. This information is encouraging investigation of the molecular and hereditary basis of the ailment and new ways to deal with its management and avoidance.