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A new cadinane sesquiterpene with significant anti-HIV-1 activity from the cultures of the basidiomycete Tyromyces chioneus

Journal of Antibiotics (2007) 60(5) 332-334
DOI: 10.1038/ja.2007.44
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Abstract

A new cadinane sesquiterpene (4β,14-dihydroxy-6α,7βH-1(10)- cadinene, 1) was isolated from the cultures of the basidiomycete, Tyromyces chioneus. Its structure was established on the basis of spectral measurements (MS, IR, 1D and 2D NMR experiments). 1 showed significant anti-HIV-1 activity with EC50=3.0 μg/ml (SI=25.4). © Japan Antibiotics Research Association.

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Liu, D. Z., Wang, F., Yang, L. M., Zheng, Y. T., & Liu, J. K. (2007). A new cadinane sesquiterpene with significant anti-HIV-1 activity from the cultures of the basidiomycete Tyromyces chioneus. Journal of Antibiotics, 60(5), 332–334. https://doi.org/10.1038/ja.2007.44

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