NG2 expressing cells in hippocampal cultures survive neurotoxic insult and retain the ability to divide

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Abstract

It has been recently proposed that NG2 proteoglycan expressing cells may stand for a unique class of glia in adult CNS referred to as oligodendrocyte progenitor cells (OPCs). These NG2 positive cells can give rise to mature oligodendrocytes, however a large number of them persists in immature stage throughout a lifetime and responds to various types of injury. In order to investigate OPCs reactivity in vitro, a model of trimethyltin evoked neurodegeneration was used. The results demonstrate that NG2 expressing cells survive treatment with the neurotoxin in a concentration that injures most of neurons in the culture. Moreover, progenitors change their morphology when treated with trimethyltin, upregulate the NG2 proteoglycan expression and retain the ability to divide.

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APA

Dzwonek, K. (2005). NG2 expressing cells in hippocampal cultures survive neurotoxic insult and retain the ability to divide. Acta Neurobiologiae Experimentalis, 65(2), 173–176. https://doi.org/10.55782/ane-2005-1551

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