Abstract
Activated protein C is an intrinsic cytoprotective, anti-inflammatory, and anticoagulant factor. It acts as an active therapeutic molecule against the progression of number of systemic disorders. APC performs majority of its cell survival and homeostatic activities through binding with EPCR and activation of PAR1. Future research on the multifunctionality of APC protein may provide a novel insight into the mechanisms and interrelation of various coagulation and systemic disorders to provide an improved pathophysiological therapeutic approach to diseases.
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CITATION STYLE
Prasad, R., Roy, A., & Sen, P. (2017). Functional aspects of activated protein C (APC) in regulating homeostasis and disease. In Proteases in Human Diseases (pp. 395–408). Springer Singapore. https://doi.org/10.1007/978-981-10-3162-5_18
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