Cystatin C: A better marker to detect coronary artery sclerosis

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Background: Nowadays, early detection and treatment can often keep chronic kidney disease patients from getting worse and prevent the occurrence of cardiovascular disease. Cystatin C (Cys-C) is a new marker for renal dysfunction. This study investigated whether Cys-C played an important role for screening coronary artery disease. Methods: The consecutive 88 outpatients (51 males and 37 females), who were suspected of having effort angina pectoris or asymptomatic ischemic heart disease, were enrolled. Serum Cys-C, which was obtained within 3 months before coronary angiography, was assessed with the presence or absence of coronary arteriosclerosis, the number of culprit arteries, and blood biochemical parameters. Results: Mean serum Cys-C was 0.82 ± 0.29 mg/l. Significant differences in the estimated creatinine clearance (p = 0.036), hemoglobin A1c (p = 0.01), left ventricular ejection fraction (p = 0.01), creatinine (p = 0.007), Cys-C (p = 0.006), and high-density lipoprotein (HDL) cholesterol (p = 0.001) were observed between the patients with or without coronary arteriosclerosis. Serum Cys-C was significantly greater in the multi-vessel disease (MVD) group than the 0 vessel disease (0VD) group (p < 0.001). HDL cholesterol was significantly lower in the MVD group than the 0VD and single-vessel disease groups (p = 0.002 and p = 0.005, respectively). Conclusion: The results of this study suggest Cys-C might be one of the risk factors for coronary arteriosclerosis in the patients with suspected ischemic heart disease without any history of coronary artery disease. Cys-C was a useful marker to detect coronary artery disease and the level of Cys-C could reflect the severity of coronary arteriosclerosis. © 2009 Japanese College of Cardiology.




Sekizuka, H., Akashi, Y. J., Kawasaki, K., Yamauchi, M., & Musha, H. (2009). Cystatin C: A better marker to detect coronary artery sclerosis. Journal of Cardiology, 54(3), 359–367.

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