Lymphomatoid granulomatosis

Abstract

Lymphomatoid granulomatosis (LG) is characterized as an angiodestructive cell proliferation. It occurs commonly in the lung, but skin manifestations are present in 45% of the patients and the involvement of the central nervous system is not rare, too. The progression into malignant lymphomas is 13-53%. The authors review the history of two patients with LG. The involvement of the lung with LG was in the first case. The histological investigation of the lung after pulmonectomy has given the diagnosis. Coombs positive hemolysis and antinuclear factor positivity were found in this patient, too. She has not been transformed into lymphoma in 3 years. In the second case LG was diagnosed after large bowel resection. After a half year follow-up the liquor investigation showed the central nervous system manifestation of lymphoma.