Cancer chemopreventive activity of lupane- and oleanane-type triterpenoids from the cones of Liquidamber styraciflua

20Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

Abstract

In a search for cancer chemopreventive agents from natural sources, four lupane-type and seven oleanane-type triterpenoids, and ten synthetic analogs were screened as potential anti-tumor promoters by using the in vitro short-term 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay. Among them, 25-acetoxy-3α-hydroxyolean-12-en-28-oic acid (1) and 3β,25-epoxy-3α-hydroxylup-20(29)-en-28-oic acid (2) were examined for anti-tumor promoting activity in a two-stage carcinogenesis assay on mouse skin with 7,12-dimethylbenz[a]anthracene (DMBA) and TPA as promoter. 25-Acetoxy-3α-hydroxyolean-12-en-28-oic acid (1) and 3β,25-epoxy-3α-hydroxylup-20(29)-en-28-oic acid (2) showed moderate inhibitory activities. © 2005 Verlag Helvetica Chimica Acta AG, Zürich.

Cite

CITATION STYLE

APA

Fukuda, Y., Sakai, K., Matsunaga, S., Tokuda, H., & Tanaka, R. (2005). Cancer chemopreventive activity of lupane- and oleanane-type triterpenoids from the cones of Liquidamber styraciflua. Chemistry and Biodiversity, 2(3), 421–428. https://doi.org/10.1002/cbdv.200590021

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free