In a search for cancer chemopreventive agents from natural sources, four lupane-type and seven oleanane-type triterpenoids, and ten synthetic analogs were screened as potential anti-tumor promoters by using the in vitro short-term 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay. Among them, 25-acetoxy-3α-hydroxyolean-12-en-28-oic acid (1) and 3β,25-epoxy-3α-hydroxylup-20(29)-en-28-oic acid (2) were examined for anti-tumor promoting activity in a two-stage carcinogenesis assay on mouse skin with 7,12-dimethylbenz[a]anthracene (DMBA) and TPA as promoter. 25-Acetoxy-3α-hydroxyolean-12-en-28-oic acid (1) and 3β,25-epoxy-3α-hydroxylup-20(29)-en-28-oic acid (2) showed moderate inhibitory activities. © 2005 Verlag Helvetica Chimica Acta AG, Zürich.
CITATION STYLE
Fukuda, Y., Sakai, K., Matsunaga, S., Tokuda, H., & Tanaka, R. (2005). Cancer chemopreventive activity of lupane- and oleanane-type triterpenoids from the cones of Liquidamber styraciflua. Chemistry and Biodiversity, 2(3), 421–428. https://doi.org/10.1002/cbdv.200590021
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