Background: Renal involvement in idiopathic hypereosinophilic syndrome is uncommon. The mechanism of kidney damage can be explained as occurring via two distinct pathways: (1) thromboembolic ischemic changes secondary to endocardial disruption mediated by eosinophilic cytotoxicity to the myocardium and (2) direct eosinophilic cytotoxic effect to the kidney. Case presentation: We present a case of a 63-year-old Caucasian man who presented to our hospital with 2 weeks of progressively generalized weakness. He was diagnosed with idiopathic hypereosinophilic syndrome with multiorgan involvement and acute kidney injury with biopsy-proven thrombotic microangiopathy. Full remission was achieved after 8 weeks of corticosteroid therapy. Conclusion: Further studies are needed to investigate if age and absence of frank thrombocytopenia can serve as a prognostic feature of idiopathic hypereosinophilic syndrome, as seen in this case.
CITATION STYLE
Curras-Martin, D., Patel, S., Qaisar, H., Mehandru, S. K., Masud, A., Hossain, M. A., … Asif, A. (2019). Acute kidney injury secondary to thrombotic microangiopathy associated with idiopathic hypereosinophilic syndrome: A case report and review of the literature. Journal of Medical Case Reports, 13(1). https://doi.org/10.1186/s13256-019-2187-4
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