Regulatory sequences in the promoter of the Dictyostelium Actin 6 gene.

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Abstract

The promoter region of the developmentally regulated Actin 6 gene of Dictyostelium has been dissected by a series of deletions. Functional analysis of the deletions in Dictyostelium transformants revealed two short regulatory sequences: a positive upstream element (PUE) between -599 and -572 which increases transcription by a factor of 10 but does not affect the developmental pattern of expression and an upstream activator sequence (UAS) between -249 and -215 which is essential for transcription and proper developmental regulation. The UAS partially coincides with a conserved sequence with dyad symmetry found upstream of several Dictyostelium actin genes (Romans and Firtel, 1985a).

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Nellen, W., Silan, C., Saur, U., & Firtel, R. A. (1986). Regulatory sequences in the promoter of the Dictyostelium Actin 6 gene. The EMBO Journal, 5(12), 3367–3372. https://doi.org/10.1002/j.1460-2075.1986.tb04652.x

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