PNR-07ASSESSMENT OF HEALTH RELATED QUALITY OF LIFE (HRQOL) IN CHILDREN AND YOUNG PEOPLE WITH MENINGIOMA

Abstract

Background/Objectives: Meningiomas are rare tumours in children, teenagers and young adults, accounting for less than 4% of primary brain tumours. The aim of this study was to review current literature reporting the disease in this population, focussing on the effects of the disease and its treatment on HRQoL, and assessment methodologies. Design/Methods: The NHS Evidence Portal was used to search Medline, PubMed, CINAHL and PsychInfo, using clearly defined search terms, matched to the encyclopaedis of each search engine. Results: Following application of exclusion criteria, duplicates and abstract review, 62 articles were included in the final literature review. The majority of studies described case reports, case series (largest 22 patients), cross sectional surveys and methodologies including case note review. Both qualitative and quantitative studies were conducted. HRQoL measures utilised included WHO QoL-100, Karnosfky Performance Scale, EORTC-QLQ-C30, with no description of validation within this population. Paediatric and TYA was of tern reported alongside adult, and often not distinguishable. No longitudinal studies were identified. Predominant treatment related effects on HRQoL included pain, fatigue, sleep disturbance and mood. Conclusion: Meningioma is a rare disease in children and young people. It is imperative that paediatric data is indentifiable when reported alongside adult patients. With the increasing use of novel treatments such as proton beam therapy, longitudinal research is essential, including the assessment HRQoL parameters (especially cognitive effects), and longterm late-effects follow-up.