Variantes de escape del virus de la hepatitis B

  • Jaramillo C
  • Navas M
N/ACitations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

The hepatitis B virus (HBV) infection is a public health problem worldwide. Considering HBV morbidity and mortality and the economic consequences .of this infection, policies and strategies to control it have been implemented, especially in regions where HBV infection is endemic, with high rates of vertical and horizontal infection. One of these strategies is the development of the recombinant vaccine. A 92% of the countries in the world have implemented the vaccine with a global coverage of 69%. The escape variants of HBV correspond to isolates with mutations in the sequence coding for the "a" determinant; these mutations result in changes in the amino acid sequence of the surface antigen (HBsAg) that prevent neutralization of viral particles by antibodies generated in response to vaccination or infection. The escape variants can infect vaccinated individuals and have been identified in the population of countries with different epidemiological patterns.

Cite

CITATION STYLE

APA

Jaramillo, C. M., & Navas, M.-C. (2015). Variantes de escape del virus de la hepatitis B. Revista Chilena de Infectología, 32(2), 190–197. https://doi.org/10.4067/s0716-10182015000300008

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free