Flexible nucleic acids (FNAs) as informational molecules: Enzymatic polymerization of fNTPs on DNA templates and nonenzymatic oligomerization of RNA on FNA templates

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Abstract

The methodology enabling enzymatic and nonenzymatic information transfer with FNAs is described. This methodology includes the chemical synthesis of fNTPs and fN phosphoramidites, in addition to protocols for the enzymatic and nonenzymatic transfer of information.

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Chemama, M., & Switzer, C. (2019). Flexible nucleic acids (FNAs) as informational molecules: Enzymatic polymerization of fNTPs on DNA templates and nonenzymatic oligomerization of RNA on FNA templates. In Methods in Molecular Biology (Vol. 1973, pp. 213–236). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9216-4_14

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