Biochemical selectivity profiling is an integral part of early drug development. Typically compounds from optimization phase are regularly tested for off-target activities within or across target families. This article presents workflow and critical aspects of biochemical protein kinase profiling based on microfluidic mobility shift assays.
CITATION STYLE
Drueckes, P. (2016). Protein kinase selectivity profiling using microfluid mobility shift assays. In Methods in Molecular Biology (Vol. 1439, pp. 143–157). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3673-1_9
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