Is it Time to Consider Use of Levo-methadone (R-(-)-Methadone) to Replace Racemic Methadone?

Abstract

Racemic methadone, a mixture of its two enantiomeric optically active forms, R-(-)-Methadone and S-(+)-Methadone (also known as levo-methadone and dextro-methadone), was first synthesized in Germany before the outbreak of World War II.