Boron-Based Enantiomerism

Abstract

Boron-based enantiomerism is fragile due to the inherent tendency of a dissociation of a ligand from tetra-coordinate chiral boron complexes under formation of the achiral tri-coordinate species. This review will present the different approaches in overcoming the inherent tendency of racemization in boron-stereogenic compounds. When embedded in an environment of chiral ligands or substituents, configurationally stable boron stereogenic centers can form in a diastereoselective manner. Compounds incorporating boron as the exclusive stereogenic center are obtained by resolution of the racemic mixtures. The recently developed – much more efficient – methods of a catalytic, enantioselective creation of boron stereogenic compounds are highlighted in this review. Finally the chiroptical properties of enantiomerically pure boron complexes that makes them promising materials or devices are addressed.