Nonalcoholic fatty liver disease and steatohepatitis

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the developed world. NAFLD is tightly linked to insulin resistance and considered to be the hepatic manifestation of the metabolic syndrome. Obesity is a well-documented risk factor for NAFLD. The cornerstone of any treatment regimen for patients with NAFLD is lifestyle modification focused on weight loss, exercise, and improvements in insulin sensitivity. Sustained and gradual weight loss is the most effective treatment for NAFLD. The roles of diet, nutrient composition, and physical activity in the management of NAFLD are outlined in this chapter.