Characteristics of hemostasis during experimental Ehrlichia canis infection

10Citations
Citations of this article
114Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: Ehrlichia canis infection in dogs can cause thrombocytopenia and clinical evidence of bleeding. It is unknown why some dogs show signs of bleeding whereas others do not despite clinically relevant thrombocytopenia. Hypothesis/Objectives: Activated platelets, decreased fibrinolysis or both mitigate bleeding tendency. Assess standard hemostatic variables, platelet dynamics, and specialized coagulation testing in dogs experimentally infected with E. canis to evaluate this clinical discrepancy. Animals: Four healthy laboratory beagles. Methods: Dogs were given blood infected with E. canis IV. Platelet indices of activation, platelet aggregometry, antiplatelet antibodies (percent IgG), complete coagulation panel, and thromboelastography (TEG) were measured before inoculation and on weeks 1-8. Dogs were treated with doxycycline at approximately 5 mg/kg PO q12h between weeks 3 and 4 (day 24). For each variable, 1-way repeated measures analysis (1-way ANOVA) with post-hoc analysis was performed with statistical significance set at P

Cite

CITATION STYLE

APA

Shropshire, S., Olver, C., & Lappin, M. (2018). Characteristics of hemostasis during experimental Ehrlichia canis infection. Journal of Veterinary Internal Medicine, 32(4), 1334–1342. https://doi.org/10.1111/jvim.15130

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free