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Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis

Marine Drugs (2013) 11(6) 1999-2012
DOI: 10.3390/md11061999
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Abstract

Three new cembrane-type diterpenoids, flexibilins A-C (1-3), along with a known cembrane, (-)-sandensolide (4), were isolated from the soft coral, Sinularia flexibilis. The structures of cembranes 1-4 were elucidated by spectroscopic methods. The structure of 4, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis. Cembrane 2 displayed a moderate inhibitory effect on the release of elastase by human neutrophils. © 2013 by the authors; licensee MDPI.

Figures

  • Figure 1. The soft coral, Sinularia flexibilis, and the structures of flexibilins A–C (1–3) and (−)-sandensolide (4).
  • Table 1. 1 H (500 MHz, CDCl3) and 13 C (125 MHz, CDCl3) NMR data and 1 H– 1 H COSY and HMBC correlations for cembrane 1.
  • Figure 2. 1 H– 1 H COSY and selected HMBC correlations (protons→quaternary carbons) for cembrane 1.
  • Figure 3. Key NOESY correlations of 1.
  • Table 2. 1 H (500 MHz, CDCl3) and 13 C (125 MHz, CDCl3) NMR data and 1 H– 1 H COSY and HMBC correlations for cembrane 2.
  • Figure 4. 1 H– 1 H COSY and selected HMBC correlations (protons→quaternary carbons) for cembrane 2.
  • Figure 5. Key NOESY correlations of 2.
  • Table 3. 1 H (500 MHz, CDCl3) and 13 C (125 MHz, CDCl3) NMR data and 1 H– 1 H COSY and HMBC correlations for cembrane 3.

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CITATION STYLE

APA

Hu, L. C., Su, J. H., Chiang, M. Y. N., Lu, M. C., Hwang, T. L., Chen, Y. H., … Sung, P. J. (2013). Flexibilins A-C, new cembrane-type diterpenoids from the Formosan soft coral, Sinularia flexibilis. Marine Drugs, 11(6), 1999–2012. https://doi.org/10.3390/md11061999

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