Abstract
Several experiments suggest that reactive oxygen metabolites generated after asbestos phagocytosis cause DNA damage. According to recent findings, crocidolite is able to induce DNA strand breaks in vitro. The aim of this study was to find out whether crocidolite asbestos fibers induce in vivo double-strand breaks in the DNA of white blood cells and in the nuclei of lung and liver. Male Wistar rats received a single tracheostoma instillation of 2.5 mg UICC crocidolite asbestos into the right lung. The same dose was injected intraperitoneally. The animals were sacrificed 4 and 13 months after instillation.
Cite
CITATION STYLE
Marczynski, B., Kerenyi, T., Marek, W., & Baur, X. (1994). Induction of DNA — Damage after Rats Exposure to Crocidolite Asbestos Fibers. In Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres (pp. 227–232). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-79041-6_21
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
