APPLICATION OF CURCUMINOIDS-LOADED NANOEMULSION FOR CANCER THERAPY

Abstract

INTRODUCTION: Curcuminoids and Oleic acid, reported in the literature as antioxidant and antitumor agents, were combined in nanoemulsion, using Pluronic F127 as a stabilizer. METHODS: The main objective is to investigate its cytotoxic activity against cancer cells. RESULTS AND DISCUSSION: The nanoemulsion show values of the particle size (251.4 ± 4.6 nm), zeta potential (-34.8 ± 1.0 mV), and pH (4.8) classifying it as stable and non-irritating for pharmacological applications. The main results indicate that, in the toxicity test in fish (Zebrafish), the nanoformulation proved to be biosafe and the evaluation of the antioxidant action (by DPPH) showed excellent antioxidant activity. Furthermore, in the vitro cytotoxicity studies, the nanoemulsions showed good cytotoxic activity, ideal for fighting Colorectal, Glioblastoma, and Leukemia cancers and more effectively in Prostate cancer.