Anti-inflammatory effects of deuterium-depleted water plus rosa damascena mill. Essential oil via cyclooxygenase-2 pathway in rats

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Abstract

Objectives: Natural medicine has been proposed for treating sepsis worldwide. Therefore, in this study, the effect of deuterium-depleted water (DDW) alone and adjuvant with Rosa damascena Mill. (RD) essential oils was considered through the evaluation of oxidative stress-antioxidant parameters and the expression of cyclooxygenase-2 (COX-2) inflammatory gene in liver damage caused by sepsis. Materials and Methods: The rats were randomly divided into 5 groups: 1) laparotomy group; 2) cecal ligation and puncture (CLP) group; 3) DDW (15 ppm and 30 ppm doses) group; 4) DDW (15 ppm and 30 ppm doses) plus RD essential oil (100 mg/kg.bw); 5) indomethacin (2 mg/kg.bw) as a positive control. The treatments were daily administrated for 2 weeks and the CLP model was created on the day 15. Then, the animals were killed and their liver tissue was separated for histopathologic and biochemical assessment. Results: Our results demonstrated that the treatment of animals with DDW and DDW plus RD essential oil was effective due to the regulation of the oxidative stress-antioxidant parameters including lipid peroxidation, glutathione (GSH), GSH s-transferases, myeloperoxidase, ferric reducing ability of plasma and inflammatory parameters such as prostaglandin E2 and COX-2. Pathological studies also showed that sepsis led to the liver tissue injuries, which can be reduced by treatments. Conclusion: Sepsis caused oxidative stress in the liver tissue, but the administration of DDW and DDW plus RD essential oil can be useful to prevent and heal these injuries.

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Fatemi, F., Golbodagh, A., Hojihosseini, R., Dadkhah, A., Akbarzadeh, K., Dini, S., & Malayeri, M. R. M. (2020). Anti-inflammatory effects of deuterium-depleted water plus rosa damascena mill. Essential oil via cyclooxygenase-2 pathway in rats. Turkish Journal of Pharmaceutical Sciences, 17(1), 99–107. https://doi.org/10.4274/tjps.galenos.2018.24381

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