Fourteen fragments and structural analogues of chemokine MCP-1 were synthesized using the Fmoc-strategy of solid phase peptide synthesis. The effect of synthesized peptides on the MCP-1-stimulated migration of mononuclear cells was examined. Both in vitro stimulants and inhibitors of the monocyte migration were found among the peptides. A possible participation of the C-terminal part of the MCP-1 molecule in the inhibition of the MCP-1-stimulated cell migration was found for the first time.
CITATION STYLE
Sidorova, M. V., Molokoedov, A. S., Aref’eva, T. I., Kukhtina, N. B., Krasnikova, T. L., Bespalova, Z. D., & Bushuev, V. N. (2004). Peptide fragments and structural analogues of chemokine MCP-1: Synthesis and effect on the MCP-1-induced migration of mononuclear cells. Russian Journal of Bioorganic Chemistry, 30(6), 523–533. https://doi.org/10.1023/B:RUBI.0000049768.98894.f5
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