The Maturing of Hormesis as a Credible Dose-Response Model

  • Calabrese E
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Abstract

Hormesis is a dose-response phenomenon that has received little recognition, credibility and acceptance as evidenced by its absence from major toxicological/risk assessment texts, governmental regulatory dose-response modeling for risk assessment, and non-visibility in major professional toxicological society national meetings. This paper traces the historical evolution of the hormetic dose-response hypothesis, why this model is not only credible but also more common than the widely accepted threshold model in direct comparative evaluation, and how the toxicological community made a critical error in rejecting hormesis, a rejection sustained over 70 years.

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Calabrese, E. J. (2003). The Maturing of Hormesis as a Credible Dose-Response Model. Nonlinearity in Biology, Toxicology, Medicine, 1(3), 154014203902499. https://doi.org/10.1080/15401420390249907

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