New insights into protein secretion: TANGO1 runs rings around the COP II coat

Abstract

In this issue, Liu et al. (2017. J. Cell Biol. https ://doi .org /10 .1083 /jcb .201611088) and Raote et al. (2017. J. Cell Biol. https ://doi .org /10 .1083 /jcb .201608080) use super-resolution microscopy to visualize large COP IIcoated endoplasmic reticulum (ER) export carriers. Rings of TAN GO1 surround COP II, implicating TAN GO1 in organizing ER exit sites and in regulating COP II coat dynamics and geometry.