Abstract
This section describes basic protocols satisfying ICH S7A recommendations for core battery CNS studies. Included are protocols for measuring general behavioral signs induced by test substances (Irwin test), effects on spontaneous locomotion (activity meter test), effects on neuromuscular coordination (rotarod test), effects on the convulsive threshold (electroconvulsive shock (ECS) threshold and PTZ seizure tests), interaction with hypnotics (barbital interaction test), and effects on the pain threshold (hot plate test).
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CITATION STYLE
Castagnè, V., Froger-Collèaux, C., Esneault, E., Marie, H. A., Lemaire, M., & Porsolt, R. D. (2013). Central nervous system (CNS) safety pharmacology studies. In Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, Second Edition (pp. 17–72). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-25240-2_3
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