Compared to other monoamine neurotransmitters, information on the association between the histaminergic system and neuropsychiatric disorders is scarce, resulting in a lack of histamine-related treatment for these disorders. The current chapter tries to combine information obtained from genetic studies, neuroimaging, post-mortem human brain studies and cerebrospinal fluid measurements with data from recent clinical trials on histamine receptor agonists and antagonists, with a view to determining the possible role of the histaminergic system in neuropsychiatric disorders and to pave the way for novel histamine-related therapeutic strategies.
CITATION STYLE
Shan, L., Bao, A. M., & Swaab, D. F. (2017). Changes in histidine decarboxylase, histamine n-methyltransferase and histamine receptors in neuropsychiatric disorders. In Handbook of Experimental Pharmacology (Vol. 241, pp. 259–276). Springer Science and Business Media, LLC. https://doi.org/10.1007/164_2016_125
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