Clinical Research in Diabetes and Obesity

Abstract

In Clinical Research in Diabetes and Obesity premier clinical scientists around the world offer an unprecedented compilation of state-of-the-art advances in clinical research on diabetes and obesity. This second volume, on Diabetes and Obesity, discusses the methods of clinical research and the interpretation of their results in studies of normal individuals, obese subjects, and patients with diabetes mellitus. Along the way, the authoritative contributors writing here illuminate how changes in the hormone action and substrate metabolism of healthy humans may lead to obesity and noninsulin-dependent diabetes mellitus. A first volume, Methods, Assessment, and Metabolic Regulation, provides the methodological basis for the present work by presenting and critically assessing the major techniques used in clinical research, as well as reviewing their use in studying healthy humans. Clinical Research in Diabetes and Obesity presents in its two wide-ranging volumes not only all of today's cutting-edge in vivo techniques, but also details approaches to elucidating the pathophysiology of these diseases, and sheds light on the latest therapeutic modalities. Its comprehensive overview of the regulation of carbohydrate, protein, and lipid metabolism in diabetic and nondiabetic humans will prove an especially valuable contribution both to the clinical science and to the care of people suffering from obesity and diabetes. I: Obesity -- 1 Energy Metabolism and Obesity -- 2 Metabolic Parameters and Energy Expenditure Before and After Weight Loss -- 3 Regulation of Food Intake and Body Weight -- 4 Mechanisms of Insulin Resistance in Obesity -- 5 Effects of Obesity on Lipid Metabolism -- II: Noninsulin-Dependent Diabetes Mellitus -- 6 Genetics of Noninsulin-Dependent Diabetes Mellitus (NIDDM) -- 7 Insulin Secretion in Type II Diabetes Mellitus -- 8 Insulin Action and Insulin Resistance in Noninsulin-Dependent Diabetes Mellitus -- 9 Dyslipidemia in Noninsulin-Dependent Diabetes Mellitus -- 10 Exercise and Noninsulin-Dependent Diabetes Mellitus (NIDDM) -- 11 Glucose Toxicity and Insulin Resistance in NIDDM -- 12 Energy Metabolism and Sympathetic Activity in Patients with Insulin Resistance -- 13 Effects of NIDDM on Vascular Tone Regulation -- III: Insights Gained from Other Insulin-Resistance Syndromes -- 14 Insulin Resistance in the Polycystic Ovary Syndrome -- 15 Dietary Management of NIDDM -- 16 Hypertension and Insulin Resistance -- 17 Lessons Learned from Clinical and Basic Research Applied to the Study of Patients with Severe Insulin Resistance -- 18 Treatment of Obesity Through Changes in Lifestyle -- 19 Syndrome X: Past, Present, and Future.