Functional state of kidneys in patients with clinical manifestations of hypothyroidism

Abstract

The research goal is to study the function of kidneys and serum concentration of immunoregulatory cytokines (IL-1β, IL-6, IL-8, IL-10) in conditions of thyroid hormone deficit. Methods - The character and severity of renal dysfunction were investigated in patients with primary hypothyroidism. The clinical examination included study of serum concentration of creatinine, urea level, potassium and natrium in blood serum, blood and urine analyses, total cholesterol, high and low density lipoproteins, daily microalbuminuria, the performing of Zimnitsky test, urinary excretion of chemokines MCP-1, RANTES, rate calculation of glomerular filtration, thyroid hormone state. Results - The renal function in clinical hypothyroidism without concomitant kidney disturbances was characterized by normal parameters o the concentrational kidney function, reduction of glomerular filtration rate, increased of serum creatinine, urea excretion level of chemokine MCP-1 and level of cytokines IL-6, IL-8 in patients with autoimmune hypothyroidism were revealed. Conclusion - It was revealed that autoimmune hypothyroidism effected balance disturbance of cytokine-producing activity of Th1 and Th2 type therefore developing autoimmune state and disease progression.