Protection of mice against mouse hepatitis virus by Corynebacterium parvum

11Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

C57BL/6 mice that are highly susceptible to infection with mouse hepatitis virus type 3 were protected against intraperitoneal viral infection by simultaneous intraperitoneal injection of Corynebacterium parvum. No protection was observed when C. parvum was given intravenously or when it was injected intraperitoneally 3 days before viral infection. Protective effects were, however, consistently found when C. parvum was given 2 h before or 2 h after viral infection. Activity was seen only against 10 50% lethal doses and not against 100 50% lethal doses. C. parvum also caused a significant decrease of virus yield in cultures of peritoneal exudate cells infected with mouse hepatitis virus type 3. These data suggest a direct effect of C. parvum on virus-susceptible cells. Injection of C. parvum in mice caused activation of natural killer (NK) cells and of interferon production. However, these two effects were equally demonstrable at high and low doses of C. parvum, whereas protection against mouse hepatitis virus type 3 was not demonstrable at low doses of C. parvum. Thus, antiviral protection may be dissociated from activation of NK cells and induction of interferon.

Cite

CITATION STYLE

APA

Schindler, L., Streissle, G., & Kirchner, H. (1981). Protection of mice against mouse hepatitis virus by Corynebacterium parvum. Infection and Immunity, 32(3), 1128–1131. https://doi.org/10.1128/iai.32.3.1128-1131.1981

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free