Class I, II, and IV histone deacetylases (HDACs) are metal-dependent enzymes involved in a broad and partly unexplored array of biological mechanisms that include epigenetic control of gene expression. The catalytic domain of human classes I and IIa enzymes has been solved in complex with a substrate peptide and inhibitors, which revealed a conserved architecture, uncovered the catalytic mechanism of deacetylation, and outlined a chemical framework for inhibitor design. We will review the different structural elements of metal-dependent HDACs and their contributions to substrate recognition, catalysis, and inhibitor specificity. © 2011 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Schapira, M. (2011). Structural biology of human metal-dependent histone deacetylases. Handbook of Experimental Pharmacology, 206, 225–240. https://doi.org/10.1007/978-3-642-21631-2_10
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