Myogenic Potential of Stem Cells: In Vivo Assessment

Abstract

tem cell therapy has been envisaged for treating disorders affecting skeletal muscle tissue. Several cell types have been identifi ed for exerting a myogenic potential in certain conditions. In order to effi ciently regenerate injured muscles while remaining safe for patients, these myogenic progenitors should present characteristics such as their availability to be isolated from patients, their growth and commitment performances and, if necessary, their capacity to be genetically corrected. Here, we present an overview of the main myogenic cell candidates that have been identifi ed and tested in vivo, classifying them by their route of delivery (intra-muscular and systemic delivery), and focusing our attention on their regenerative capacity in animal models of Duchenne muscular dystrophy.