TRP channels in urinary bladder mechanosensation

Abstract

The lower urinary tract has two main functions: storage and periodic elimination of urine [1]. These functions are controlled by complex neural circuits of reflex pathways located in the brain, the spinal cord and the periphery. The lower urinary tract constantly sends mechanosensory information to the central nervous system via afferent pathway. These signals generate sensation and trigger voiding responses. Alterations in afferent activity may lead to lower urinary tract dysfunction. The increase of afferent excitability is one of mechanisms for overactive bladder syndrome and for painful bladder syndrome [1, 2]. However, the precise mechanisms by which mechanical stimuli excite bladder afferents remain unclear. © 2011 Springer Science+Business Media B.V.