Edwin G. Krebs (1918–2009)

Abstract

Defining how protein phosphorylation is regulated led to an explosion of knowledge about most cellular processes.Edwin G. Krebs, a giant of biomedical science in the 20th century, died on 21 December from congestive heart failure in Seattle at the age of 91. His discovery (with Edmond H. Fischer) of protein phosphorylation as a regulatory mechanism touched all aspects of biomedical science and profoundly influenced therapeutic approaches now used in clinical care. Ed's life epitomizes commitment to family, excellence in research, and academic service.