Cicatrización de injertos cutáneos en malla de espesor completo utilizando azúcar granulado versus nitrofurazona en caninos

Abstract

The aim of this study was to evaluate the healing process of full-thickness mesh skin graft using two topical treatments: granulated sugar vs. nitrofurazone. For this purpose, four animals of the same litter were manipulated with equal sanitary handling and similar environmental and nutritional conditions. The experimental animals were divided in two groups: first group was treated with 0.2[%] nitrofurazone, second group with granulated sugar. Results were measured in function of healing time (in days) considering variables such as total healing time, mesh cavity filling time, and time of removal. Healing time of skin graft was shorter in the dogs treated with granulated sugar (42 days) compared to those treated with nitrofurazone (54 days), although the differences were not significant. On the other hand, significant differences (p<0.05) were found for the time of mesh cavity filling and time of bandage removal, being both variables shorter for the animals treated with sugar. Histopathological studies revealed that the latter developed appropriate scaring processes characterized by the uniformity of the epidermal stratum and parallelism of the collagen fibers. On the other hand, animals treated with nitrofurazone exhibited abnormal patterns and presence of inflammatory cells.