Insulin-like growth factor initiates hepatocellular carcinoma in chronic hepatitis c virus patients through induction of long non-coding ribonucleic acids af085935

Abstract

BACKGROUND: Hepatitis C virus (HCV) is the most commonly occurring hepatic infection worldwide. Chronic HCV infection usually complicated with cirrhosis and even hepatocellular carcinoma (HCC) with significant morbidity and mortality. AIM: The aim of this study was to clarify the molecular mechanism by which HCV can induce HCC and identify a new diagnostic marker for early detection of HCC. METHODS: A total of 180 participating subject were divided into three groups: Group 1: 60 healthy individuals (controls), Group 2: 60 HCV-infected patients, and Group 3: 60 HCV patients developed HCC. Serum insulin-like growth factor (IGF), Forkhead box class O (FOXO), and long non-coding ribonucleic acid (LncRNA) AF085935 were evaluated. RESULTS: Serum IGF was significantly elevated in HCV and HCC patients, while FOXO and LncRNA AF085935 were significantly upregulated in HCC. IGF significantly correlated with and LncRNA AF085935. CONCLUSION: HCV can induce IGF with subsequent induction of LncRNA AF085935 and FOXO.