Parkinson's disease is the second most common neurodegenerative disorder. Although the pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α-synuclein has long been considered as an important risk factor. Elucidating the mechanisms that influence the aggregation of α-synuclein is essential for developing an effective diagnostic, preventative and therapeutic strategy to treat this devastating disease. The aggregation of α-synuclein is influenced by several post-translational modifications. Here, we summarized the major post-translational modifications (phosphorylation, ubiquitination, truncation, nitration, O-GlcNAcylation) of α-synuclein and the effect of these modifications on α-synuclein aggregation, which may provide potential targets for future therapeutics.
CITATION STYLE
Zhang, J., Li, X., & Li, J. D. (2019). The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases. Frontiers in Neuroscience. Frontiers Media S.A. https://doi.org/10.3389/fnins.2019.00381
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