Interaction between protein complexes and the genome mediates essential functions including gene regulation, genome integrity, and chromatin organization. Recent advances in chromatin immunoprecipitaion (ChIP)-chip and ChIP-Seq technologies have enabled genome-wide identification of occupancy of transcription factors and modified histones that is critical for uncovering gene regulatory networks. This review discusses ChIP-chip and ChIP-Seq technology, their pitfalls, insights from genome-wide occupancy studies, and applications pertaining to vertebrate retina. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Hao, H. (2012). Genome-wide occupancy analysis by ChIP-chip and ChIP-Seq. In Advances in Experimental Medicine and Biology (Vol. 723, pp. 753–759). https://doi.org/10.1007/978-1-4614-0631-0_96
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