The alignment of sequencing reads against a protein reference database is a major computational bottleneck in metagenomics and data-intensive evolutionary projects. Although recent tools offer improved performance over the gold standard BLASTX, they exhibit only a modest speedup or low sensitivity. We introduce DIAMOND, an open-source algorithm based on double indexing that is 20,000 times faster than BLASTX on short reads and has a similar degree of sensitivity.
CITATION STYLE
Buchfink, B., Xie, C., & Huson, D. H. (2014, January 1). Fast and sensitive protein alignment using DIAMOND. Nature Methods. Nature Publishing Group. https://doi.org/10.1038/nmeth.3176
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