Antinociceptive And Antiinflammatory Effects Of Essential Oil Of Dennettia tripetala G.Baker (Annonaceae) In Rodents

Abstract

In this study we evaluated the analgesic and anti- inflammatory activities of the essential oil (EO) of the fruits ofDennettia tripetala in rodents. The plant is a tropical African plant and the fruits are commonly eaten as spices and consumed as a stimulant, and its various parts are used in the treatment of fever, cough and as anti-emetics.The analgesic effects of the oil was assessed in mice using the hot plate, acetic acid-induced writhings and formalin test, while carrageenan-induced paw oedema was used to study the antiinflammatory effects in rats. The EO at 25-50 mg/kg exhibited significant (p