Extracellular matrix remodelling in the endometrium and its possible relevance to the pathogenesis of endometriosis

68Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.

Abstract

Essential features of endometrial physiology involve the extracellular matrix (ECM). In the pathogenesis of endometriosis, interactions of endometriosis cells with ECM can be postulated. Two systems of secreted proteases in the endometrium, the plasmin(ogen) activator/inhibitor and the matrix metalloproteinases and their inhibitors were examined in cell cultures of uterine endometrial cells from women with and without endometriosis. Soluble urokinase receptor secretion is increased, and mRNA transcription of tissue inhibitor of metalloproteinases-2 (TIMP-2) is upregulated by progestin in endometriosis. These findings are compatible with an altered ECM turnover in the endometrium of these patients that may explain a higher invasive potential of retrogradely menstruated endometrial fragments.

Cite

CITATION STYLE

APA

Sillem, M., Prifti, S., Neher, M., & Runnebaum, B. (1998). Extracellular matrix remodelling in the endometrium and its possible relevance to the pathogenesis of endometriosis. In Human Reproduction Update (Vol. 4, pp. 730–735). https://doi.org/10.1093/humupd/4.5.730

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free