A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

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Abstract

Structural analysis of an endogenous human SWI/SNF complex shows how it engages with nucleosomes and provides insight into how cancer-associated mutations affect the remodeler's function.

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Mashtalir, N., Suzuki, H., Farrell, D. P., Sankar, A., Luo, J., Filipovski, M., … Kadoch, C. (2020). A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms. Cell, 183(3), 802-817.e24. https://doi.org/10.1016/j.cell.2020.09.051

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