Immunomodulatory therapies

Abstract

Immunosuppressive drugs constitute a heterogeneous group of therapeutic compounds each with a unique mode of action and toxicity profile (Table 48.1). Their main function is to dampen the immune system-notably T and B lymphocytes-functionally and/or numerically, hence their utility in inducing remission and control of specific rheumatic manifestations that result from inflammation. In contrast to immunoablative therapy and stem cell transplantation (discussed elsewhere), immunosuppressive drugs do not permanently correct the fundamental imbalance of immune regulation in autoimmune disease and, as such, they have only limited curative potential when used in standard doses.