Selected Topics in Chronic Lymphocytic Leukemia Pathogenesis

Abstract

Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in Western countries mainly affecting individuals older than 50 years. It follows an extremely variable course, with survival ranging from months to decades. Available treatments often induce remissions, though almost all patients relapse and CLL remains an incurable disease [1]. However, recent advances in molecular biology have enabled us to better understand the disease physiopathology and together with the development of new therapeutic agents have made the management of the disease more rational and more effective.