Purpose: The temporal profiles of the effects of intracisternal injection of magnesium sulfate (MgSO4) on vasodilation and cerebrospinal fluid (CSF) magnesium ion (Mg2+) concentration were investigated in the canine subarachnoid hemorrhage (SAH) model. Method: Cerebral vasospasm was induced using the two-hemorrhage model in seven female beagles. On day 7, 0.5 ml/kg of 15 mmol/l MgSO4 in Ringer solution was injected into the cerebellomedullary cistern. Angiography was performed on day 1 (before SAH), and before and 1, 3, and 6 h after the intracisternal injection on day 7. CSF Mg2+ was measured at the same time. Results: The diameters of the basilar artery (BA), vertebral artery (VA), and superior cerebellar artery (SCA) before the intracisternal injection on day 7 were 0.59 ± 0.15, 0.41 ± 0.17, and 0.35 ± 0.17 mm, respectively, and were significantly decreased (p < 0.01) compared with the baseline diameters on day 1. The BA diameters at 1 h (0.74 ± 0.16 mm) and 3 h (0.73 ± 0.13 mm), the VA diameter at 1 h (0.64 ± 0.14 mm), and the SCA diameter at 3 h (0.54 ± 0.08 mm) after the injection were significantly increased (p < 0.05). The CSF Mg2+ concentration was significantly increased (p < 0.01) at 1 h (3.59 ± 0.76 mEq/l) and 3 h (2.00 ± 0.31 mEq/l) after the injection compared with the baseline value (1.35 ± 0.23 mEq/l). Conclusions: The reversible effect of intracisternal MgSO4 solution injection on the spastic artery depends on maintenance of the optimal CSF Mg2+ concentration. © Springer-Verlag/Wien 2011.
CITATION STYLE
Mori, K., Miyazaki, M., Hara, Y., Aiko, Y., Yamamoto, T., Nakao, Y., & Esaki, T. (2011). Temporal profile of the effects of intracisternal injection of magnesium sulfate solution on vasodilation of spastic cerebral arteries in the canine SAH model. In Acta Neurochirurgica, Supplementum (Vol. 110, pp. 39–42). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-0356-2_8
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