Factors relating to urinary protein excretion in children with autosomal dominant polycystic kidney disease

50Citations
Citations of this article
20Readers
Mendeley users who have this article in their library.

Abstract

Adults with autosomal dominant polycystic kidney disease (ADPKD) who have overt proteinuria (>300 mg/d) have higher mean arterial pressures, lower creatinine clearances, larger renal volumes, and a more aggressive course of renal disease than ADPKD patients without proteinuria. This study examines the relationship between proteinuria and microalbuminuria and similar factors in ADPKD children. A total of 189 children from 81 ADPKD families was included in the analysis. The ADPKD children (n = 103) had significantly greater urine protein excretion rates than the non-ADPKD children (n = 86) (3.9 ± 0.3 versus 2.8 ± 0.2 mg/m2 per h, P < 0.001). Children with severe renal cystic disease (>10 cysts; n = 54) had greater protein excretion than those with moderate disease (≤10 cysts; n = 49) (4.4 ± 0.5 versus 3.3 ± 0.2 mg/m2 per h, P < 0.05). The ADPKD children had significantly greater albumin excretion rates than the non-ADPKD children (32 ± 6 versus 10 ± 2 mg/m2 per 24 h, P < 0.001), and a higher percentage of ADPKD children had significant microalbuminuria (> 15 mg/m2 per 24 h in boys and >23 mg/m2 per 24 h in girls) than their unaffected siblings (30% versus 10%, P < 0.05). Thirty percent of ADPKD children had albuminuria and 23% had overt proteinuria. For all ADPKD children, there was no correlation between proteinuria and hypertension. However, there was a significant correlation between urinary protein excretion and diastolic BP among children diagnosed after the first year of life (r = 0.23, P < 0.05). Therefore, proteinuria and albuminuria occur early in the course of ADPKD and may be markers of more severe renal disease.

Cite

CITATION STYLE

APA

Sharp, C., Johnson, A., & Gabow, P. (1998). Factors relating to urinary protein excretion in children with autosomal dominant polycystic kidney disease. Journal of the American Society of Nephrology, 9(10), 1908–1914. https://doi.org/10.1681/asn.v9101908

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free