Left ventricular shape variation in patients with aortic coarctation pre- and post-stent implantation

Abstract

Background: Coarctation of the aorta (CoA) affects about 4 out of every 10,000 babies born and requires lifelong follow-up. Even after successful early repair, late cardiovascular (CV) complications arise. In adult patients, left ventricular remodeling (LVR) patterns can predict CV risk. However, few studies on LVR of CoA patients exist due to lack of detailed geometric models. The Cardiac Atlas Project (CAP), a worldwide consortium for pooling standardized analyses of cardiac images for mapping heart shape and motion, provides a unique opportunity to study CoA cardiac remodeling. This study compares LV shape in a sample of CoA patients pre- and post-stent to normal patients from the CAP with the goal of developing model-based predictions of LVR to guide clinical management. Methods: Cardiac magnetic resonance images (CMRI) and clinical data of five patients (Ages: 8-24 yrs.) with native and re-coarctation of the aorta were collected with IRB approval. All study patients were potential candidates for stent implantation. CMRI 1-2yrs. post-stent are currently available for four patients. Patient-specific geometric models were built from CMRI using finite element guide-point modeling software (CIM, University of Auckland, New Zealand). Shape modes at end-systole (ES) and end-diastole (ED) were derived using principal component analysis (PCA) of a population (n = 1991) of asymptomatic volunteers from the CAP. PC scores describing the deviation of each CoA model from the asymptomatic PCA model distribution at ED and ES for various shape modes were calculated. Results: Figure 1 shows representative geometric models for a single patient and Table 1 reports PC scores for all patients. In order, PC modes (M1-M4) represent variance in: 1) LV size, 2) sphericity and wall thickness, 3) mitral valve orientation (MVO), and 4) wall thickness and MVO. Most PC scores are <2.0, indicating model shapes are within two standard deviations of the control population. At ED and ES pre-stent, the largest absolute PC score for most patients is for M4, which predominantly represents wall thickness and MVO. Generally, as the value for M4 poststent decreases, the mode with the largest absolute PC changes for a particular patient even at one year post-stent. This is consistent with recent literature showing that short-term LVR may occur in CoA patients post-intervention. Conclusions: Preliminary results with a small sample size comparing LV geometry of CoA patients against an atlas-based population of controls show LV shape characteristics that are similar to the normal LV. Notable characteristics post-stent include change in wall thickness and mitral valve orientation which reflect remodeling of the ventricle. Detailed quantification of cardiac shape can improve our understanding of the adverse effects of remodeling and, in combination with future patientspecific biomechanics models, advance the potential for early recognition of remodeling patterns to guide timely clinical management. (Table presented).