Adjuvants in EAE

Abstract

Adjuvants enhance autoantigens' immunogenicity and play a major role in the induction of EAE. Complete Freund's adjuvant (CFA) is the key adjuvant for cell-mediated immunity, including EAE. An additional adjuvant, pertussis toxin, is necessary for active EAE in mice. The mechanisms of action of adjuvants are multiple, but important actions are stimulation of proinflammatory cytokines and costimulatory molecules.