DMF mediated Henry reaction of isatins: An efficient synthesis of 3-hydroxy-2-oxindole

Abstract

An efficient Henry reaction has been described for the synthesis of 3-hydroxy-3-(nitroalkyl)-2-oxindole by the reaction of isatins with nitroalkanes in N,N-dimethylformamide (DMF) under anhydrous condition. This method provides high yield of 3-hydroxy-2-oxindoles under mild reaction condition. Moreover, the procedure is environmentally benign in nature, efficient, and applicable to variety of isatins as well as nitroalkanes. © 2013 Copyright Harshadas M. Meshram, Pramod B. Thakur, Madhu B. Bejjam and Vikas M. Bangade.