RAGs usurp cellular factors for both breaking and repairing

Abstract

There is clear evidence that the recombination-activating gene (RAG) complex functions best in vitro with help from the high-mobility group box 1 (HMGB1) DNA-bending protein. In this issue of Blood, Thwaites et al show unequivocally that HMGB1 is similarly required for RAG cleavage in vivo.1