A novel approach for detection of functional expression of TRPV1 channels on regenerated neurons following nerve injury

6Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

Transient receptor potential vanilloid 1 (TRPV1) is a polymo-dal receptor channel, which plays an important role in pain transduction. It is important to understand the functional expression of this channel under neuropathic pain (NP) conditions. A novel method was used to investigate the dynamics of functional expression of this channel on regenerated neurons under NP conditions following trigeminal nerve injury using a combination of a permanently charged sodium channel blocker (QX-314) and a TRPV1 agonist (capsaicin; QX-CAP). The combination was originally introduced as a local anesthetic. Synchronization between the local anesthetic effect of QX-CAP and TRPV1 expression on regenerated neurons was observed following the nerve injury. QX-CAP had no local anesthetic effect under NP conditions 2 weeks after the injury when TRPV1 expression on regenerated neurons was low. However, this combination was effective under NP conditions 3 and 4 weeks following injury when TRPV1 expression in regenerated neurons was moderate to high. The current review, discusses the potential of QX-314 as a local anesthetic and a novel approach of using QX-CAP to reveal the dynamics of functional expression of TRPV1 on regenerated neurons following trigeminal nerve injury.

References Powered by Scopus

The capsaicin receptor: A heat-activated ion channel in the pain pathway

7739Citations
N/AReaders
Get full text

The cloned capsaicin receptor integrates multiple pain-producing stimuli

2738Citations
N/AReaders
Get full text

Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction

1448Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain

34Citations
N/AReaders
Get full text

Co-application of eugenol and QX-314 elicits the prolonged blockade of voltage-gated sodium channels in nociceptive trigeminal ganglion neurons

12Citations
N/AReaders
Get full text

Neuroprotective effect of nypa fruticans wurmb by suppressing trpv1 following sciatic nerve crush injury in a rat

4Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Zakir, H. M., Masuda, Y., & Kitagawa, J. (2020). A novel approach for detection of functional expression of TRPV1 channels on regenerated neurons following nerve injury. Journal of Oral Science. Nihon University, School of Dentistry. https://doi.org/10.2334/josnusd.19-0356

Readers' Seniority

Tooltip

Professor / Associate Prof. 2

33%

PhD / Post grad / Masters / Doc 2

33%

Lecturer / Post doc 1

17%

Researcher 1

17%

Readers' Discipline

Tooltip

Medicine and Dentistry 4

57%

Chemistry 1

14%

Nursing and Health Professions 1

14%

Engineering 1

14%

Save time finding and organizing research with Mendeley

Sign up for free